The Influence of C‐Hepatitis on C‐Reactive Protein in a Cohort of Brazilian Hemodialysis Patients
Identifieur interne : 005657 ( Main/Exploration ); précédent : 005656; suivant : 005658The Influence of C‐Hepatitis on C‐Reactive Protein in a Cohort of Brazilian Hemodialysis Patients
Auteurs : M. M. Nascimento ; A. Bruchfeld [Suède] ; M. E. Suliman [Suède] ; S. Y. Hayashi [Suède] ; R. Pecoits-Filho [Suède] ; R. C. Manfro ; M. A. Pachaly ; L. Renner ; P. Stenvinkel [Suède] ; M. C. Riella ; B. Lindholm [Suède]Source :
- Hemodialysis International [ 1492-7535 ] ; 2004-01.
Abstract
Background: The aim of this study was to investigate the influence of HCV on two markers of systemic inflammation, serum CRP, and interleukin‐6 (IL‐6) in HD patients. Methods: The study included 118 HD patients (47% males, age 47 ± 13 years, 9% diabetics) who were treated by on standard HD for at least 6 months. The patients were divided in two groups, depending on the presence (HCV+) or absence (HCV–) of serum antibodies against HCV. Serum albumin (S‐Alb), plasma high sensitivity CRP (hsCRP), IL‐6, and alanine aminotransferase (ALT) were measured, and the values were compared with 22 healthy controls. Results: The median of hsCRP, IL‐6, and the hsCRP/IL‐6 ratio were: 3.5 vs. 2.1 mg/L, p < 0.05; 4.3 vs. 0.9 pg/mL, p < 0.0001; and 0.8 vs. 2.7 pg/mL, p < 0.0001 for patients and controls, respectively. Age, gender, S‐Alb, IL‐6, and hsCRP did not differ between the HCV+ and HCV– patients. However, HCV+ patients had higher ALT (29 ± 21 vs. 21 ± 25 UI/L) and had been a longer time on HD (6.1 ± 3.0 vs. 4.0 ± 2.0 years) (p < 0.0001), respectively. Moreover, HCV+ patients had a significantly lower median hsCRP/IL‐6 ratio (0.7 vs. 0.9; p < 0.05) as compared to the HCV group. Conclusion: The finding that the hsCRP/IL‐6 ratio was lower in HCV+ patients than in HCV– patients suggests that hsCRP may be a less useful marker of inflammation in HCV+ patients and that a different cut‐off value for hsCRP may be required to define inflammation in HD patients.
Url:
DOI: 10.1111/j.1492-7535.2004.0085bj.x
Affiliations:
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Suliman</name><affiliation wicri:level="3"><country xml:lang="fr">Suède</country><wicri:regionArea>Divisions of Renal Medicine and Baxter Novum, Department of Clinical Science, Karolinska Institutet, Huddinge University Hospital, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Hayashi, S Y" sort="Hayashi, S Y" uniqKey="Hayashi S" first="S. Y." last="Hayashi">S. Y. Hayashi</name><affiliation wicri:level="3"><country xml:lang="fr">Suède</country><wicri:regionArea>Divisions of Renal Medicine and Baxter Novum, Department of Clinical Science, Karolinska Institutet, Huddinge University Hospital, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Pecoits Ilho, R" sort="Pecoits Ilho, R" uniqKey="Pecoits Ilho R" first="R." last="Pecoits-Filho">R. Pecoits-Filho</name><affiliation></affiliation><affiliation wicri:level="3"><country xml:lang="fr">Suède</country><wicri:regionArea>Divisions of Renal Medicine and Baxter Novum, Department of Clinical Science, Karolinska Institutet, Huddinge University Hospital, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Manfro, R C" sort="Manfro, R C" uniqKey="Manfro R" first="R. C." last="Manfro">R. C. Manfro</name><affiliation><wicri:noCountry code="no comma">Pontificia Universidade Catolica do Paraná‐Brazil</wicri:noCountry></affiliation></author><author><name sortKey="Pachaly, M A" sort="Pachaly, M A" uniqKey="Pachaly M" first="M. A." last="Pachaly">M. A. Pachaly</name><affiliation><wicri:noCountry code="no comma">Faculdade Evangélica de Medicina do Paraná‐Brazil</wicri:noCountry></affiliation></author><author><name sortKey="Renner, L" sort="Renner, L" uniqKey="Renner L" first="L." last="Renner">L. Renner</name><affiliation><wicri:noCountry code="no comma">Faculdade Evangélica de Medicina do Paraná‐Brazil</wicri:noCountry></affiliation></author><author><name sortKey="Stenvinkel, P" sort="Stenvinkel, P" uniqKey="Stenvinkel P" first="P." last="Stenvinkel">P. Stenvinkel</name><affiliation wicri:level="3"><country xml:lang="fr">Suède</country><wicri:regionArea>Divisions of Renal Medicine and Baxter Novum, Department of Clinical Science, Karolinska Institutet, Huddinge University Hospital, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Riella, M C" sort="Riella, M C" uniqKey="Riella M" first="M. C." last="Riella">M. C. Riella</name><affiliation></affiliation><affiliation><wicri:noCountry code="no comma">Post‐Graduation Nephrology Program of Universidade Federal do Rio Grande do Sul‐Brazil</wicri:noCountry></affiliation></author><author><name sortKey="Lindholm, B" sort="Lindholm, B" uniqKey="Lindholm B" first="B." last="Lindholm">B. Lindholm</name><affiliation wicri:level="3"><country xml:lang="fr">Suède</country><wicri:regionArea>Divisions of Renal Medicine and Baxter Novum, Department of Clinical Science, Karolinska Institutet, Huddinge University Hospital, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Hemodialysis International</title><title level="j" type="alt">HEMODIALYSIS INTERNATIONAL</title><idno type="ISSN">1492-7535</idno><idno type="eISSN">1542-4758</idno><imprint><biblScope unit="vol">8</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="102">102</biblScope><biblScope unit="page" to="102">102</biblScope><biblScope unit="page-count">100</biblScope><publisher>Blackwell Science Inc</publisher><pubPlace>Oxford, UK; Malden, USA</pubPlace><date type="published" when="2004-01">2004-01</date></imprint><idno type="ISSN">1492-7535</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1492-7535</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background: The aim of this study was to investigate the influence of HCV on two markers of systemic inflammation, serum CRP, and interleukin‐6 (IL‐6) in HD patients. Methods: The study included 118 HD patients (47% males, age 47 ± 13 years, 9% diabetics) who were treated by on standard HD for at least 6 months. The patients were divided in two groups, depending on the presence (HCV+) or absence (HCV–) of serum antibodies against HCV. Serum albumin (S‐Alb), plasma high sensitivity CRP (hsCRP), IL‐6, and alanine aminotransferase (ALT) were measured, and the values were compared with 22 healthy controls. Results: The median of hsCRP, IL‐6, and the hsCRP/IL‐6 ratio were: 3.5 vs. 2.1 mg/L, p < 0.05; 4.3 vs. 0.9 pg/mL, p < 0.0001; and 0.8 vs. 2.7 pg/mL, p < 0.0001 for patients and controls, respectively. Age, gender, S‐Alb, IL‐6, and hsCRP did not differ between the HCV+ and HCV– patients. However, HCV+ patients had higher ALT (29 ± 21 vs. 21 ± 25 UI/L) and had been a longer time on HD (6.1 ± 3.0 vs. 4.0 ± 2.0 years) (p < 0.0001), respectively. Moreover, HCV+ patients had a significantly lower median hsCRP/IL‐6 ratio (0.7 vs. 0.9; p < 0.05) as compared to the HCV group. Conclusion: The finding that the hsCRP/IL‐6 ratio was lower in HCV+ patients than in HCV– patients suggests that hsCRP may be a less useful marker of inflammation in HCV+ patients and that a different cut‐off value for hsCRP may be required to define inflammation in HD patients.</div></front></TEI><affiliations><list><country><li>Suède</li></country><region><li>Svealand</li></region><settlement><li>Stockholm</li></settlement></list><tree><noCountry><name sortKey="Manfro, R C" sort="Manfro, R C" uniqKey="Manfro R" first="R. C." last="Manfro">R. C. Manfro</name><name sortKey="Nascimento, M M" sort="Nascimento, M M" uniqKey="Nascimento M" first="M. M." last="Nascimento">M. M. Nascimento</name><name sortKey="Pachaly, M A" sort="Pachaly, M A" uniqKey="Pachaly M" first="M. A." last="Pachaly">M. A. Pachaly</name><name sortKey="Renner, L" sort="Renner, L" uniqKey="Renner L" first="L." last="Renner">L. Renner</name><name sortKey="Riella, M C" sort="Riella, M C" uniqKey="Riella M" first="M. C." last="Riella">M. C. Riella</name></noCountry><country name="Suède"><region name="Svealand"><name sortKey="Bruchfeld, A" sort="Bruchfeld, A" uniqKey="Bruchfeld A" first="A." last="Bruchfeld">A. Bruchfeld</name></region><name sortKey="Hayashi, S Y" sort="Hayashi, S Y" uniqKey="Hayashi S" first="S. Y." last="Hayashi">S. Y. Hayashi</name><name sortKey="Lindholm, B" sort="Lindholm, B" uniqKey="Lindholm B" first="B." last="Lindholm">B. Lindholm</name><name sortKey="Pecoits Ilho, R" sort="Pecoits Ilho, R" uniqKey="Pecoits Ilho R" first="R." last="Pecoits-Filho">R. Pecoits-Filho</name><name sortKey="Stenvinkel, P" sort="Stenvinkel, P" uniqKey="Stenvinkel P" first="P." last="Stenvinkel">P. Stenvinkel</name><name sortKey="Suliman, M E" sort="Suliman, M E" uniqKey="Suliman M" first="M. E." last="Suliman">M. E. Suliman</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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